Endocrine Abstracts

A 21-year-old woman presented in 2015 with palpitations, weight and hair loss, mood swings and diarrhoea. She was diagnosed with thyrotoxicosis (Table). On examination, thyroid was normal and no evidence of opthalmopathy. Treatment with Propranolol and Carbimazole was commenced.  Ultrasound neck revealed moderate diffuse enlargement of the thyroid with uniformly abnormal echotexture, consistent with thyroiditis.  A month later, she developed profound hypothyroidism, therefore Carbimazole was ...

A 65-year-old gentleman was referred by his GP because of acute kidney injury and hypercalcaemia, which was associated with low levels of parathyroid hormone. He had been fit and well and was on no regular medications. Whilst his hypercalcaemia was partly correctible with saline rehydration, cautious use of bisphosphonates and cinacalcet were not effective in preventing rebound, and his nephropathy persisted. Curiously, he had longstanding low plasma alkaline phosphatase, but had normal denti...